Spore-based probiotic 60 capsules
The spore probiotic clinically shown to recondition the gut
The world's most clinically studied spore-based probiotic — formulated to actively recondition the gut microbiome.
By Microbiome Labs
MegaSporeBiotic is a 100% spore-based probiotic containing five Bacillus spore strains. Spore-form probiotics survive stomach acid, establish in the small intestine and produce meaningful, clinically documented changes to the gut microbiome.
Microbiome Labs' MegaSporeBiotic 60 capsules
MegaSporeBiotic is a 100% spore-based, broad-spectrum probiotic clinically shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health promoting, commensal gut bacteria.
100% spore based - naturally designed to survive digestion, colonizes, and increases microbial diversity in the gut, reduces systemic inflammation and provides immune support.
Increases butyrate production, which has been shown to reduce the inflammatory process in the gut. The spores are multi-functional, maintaining efficacy for a broad range of conditions.
Contains Bacillus Coagulans, B.Indicus (HU36), B.Licheniformis, B.Subtilis (HU58) and B.Clausii.
MegaSpore Biotic boasts a 5-year shelf-life, does not require refrigeration, and maintains efficacy during antibiotic therapy.
Per bottle: 60 capsules
Suggested use Adults: Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol.
If 1 capsule every other day is too strong, try starting with 1/2 capsules or even 1/4 capsule in some cases.
Possible symptoms may include abdominal cramping, loose stools, and changes in bowel movements. Though these symptoms may be uncomfortable, they are a sign that the product is working! Symptoms should resolve within 2-3 days.
Please use this product under the supervision of a trained practitioner.
Week 1 1 capsule every other day
Week 2 1 capsule daily
Week 3+ 2 capsules daily
Product Education:
The 1st probiotic to PROTECT its human hostMega Spore Biotic is a probiotic blend of 5 Bacillus spores that have been clinically shown to maintain healthy gut barrier function and overall immunity. The bi-phasic life cycle of the Bacillus spores allows them to remain dormant in harsh environments until they reach more favourable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing in the gut. This unique probiotic blend aims to RECONDITION the gut instead of reseeding with probiotic strains that cannot survive digestion or colonize the gut. MegaSporeBiotic™ has quickly become a household favourite among health practitioners and consumers alike.
Ingredients Bacillus Licheniformis:
Produces proteases needed for protein digestion
Produces a full spectrum of B vitamins
Bacillus indicus HU36:
Produces RDA levels of carotenoids: lycopene, astaxanthin, beta-carotene, and lutein
Produces quinols and vitamins
Bacillus subtilis HU58:
Produces nattokinase and vitamin K2
Supports healthy GALT development
Bacillus clausii:
Supports immune function
Maintains efficacy during antibiotic treatment
Bacillus coagulans:
Produces L+ optical form of lactic acid
Supports immune function
Warnings Caution: If you
What's in it
| Ingredient | Form | Dose | Notes |
|---|---|---|---|
| Bacillus indicus HU36 | Spore form | Total 4 billion CFU across all five strains per serving | The only known carotenoid-producing Bacillus strain. Produces antioxidant carotenoids including lycopene, beta-carotene and astaxanthin directly in the gut. |
| Bacillus subtilis HU58 | Spore form | See total CFU above | Produces nattokinase and bacitracin. Strongly supports microbiome diversity and SCFA production. |
| Bacillus coagulans | Spore form | See total CFU above | One of the most clinically studied Bacillus strains for digestive comfort and IBS-related symptoms. |
| Bacillus licheniformis | Spore form | See total CFU above | Produces protease and lipase enzymes that support protein and fat digestion in the gut. |
| Bacillus clausii |
How to take
- Start with 1 capsule daily with the largest meal for the first 1–2 weeks (to allow gradual adaptation), then increase to 2 capsules daily. May be opened and mixed into food or beverages.
Clinical evidence
- McFarlin et al. (2017) — Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers (World Journal of Gastrointestinal Pathophysiology) MegaSporeBiotic RCT demonstrating reduced endotoxaemia
- Khalesi et al. (2019) — A review of probiotic supplementation in healthy adults: helpful or hype? (European Journal of Nutrition) Probiotic evidence review including spore-based strains